Genetic risk factors for breast cancer may threaten heart health

A pair of mutations to the BRCA1 and BRCA2 genes are known to significantly increase a woman's risk of developing breast cancer and potentially requiring a prescription to buy Tamoxifen. Now, new research suggests that these mutations may also lead to a higher risk of suffering a heart attack and dying from complications.

Researchers from St. Michael's Hospital in Toronto examined the heart health of groups of mice that were bred to exhibit either of the genetic mutations. Mice with the BRCA1 gene were significantly more likely to suffer a heart attack. Furthermore, they were three to five times more likely to die from heart failure.

"Our findings suggest that individuals who are at risk of breast cancer may also be at a previously unrecognized risk of heart disease," said Dr. Subodh Verma, who led the study. "More importantly, we now understand that breast cancer and heart disease have a common biological basis."

The results of the study also indicate that women taking a prescription to buy Tamoxifen may also benefit from taking steps to support their heart health.